left4dead
"Safe house ahead!"
The Survivors
The exit door to a safe room.

The exit door to a safe room.

Officially termed a safe room (also known as a safe house), this is the mission goal in both Left 4 Dead and Left 4 Dead 2 chapters save for finales. Once all Survivors are inside a safe room and have closed the door, the chapter's results and/or scores will roll and the next chapter will load.

Appearance

A safe room is a barricaded room or building which enables Survivors to rest, heal and resupply themselves. In Campaign Mode, they also give teams a chance to take a break and discuss plans for the next chapter. Safe rooms are easily identified by red, heavily armored metal doors. Chapter ending doors are solid and have only a peephole. Chapter starting doors are fundamentally different in design, being locked with a crash-bar and featuring a large aperture window providing a wide field of view, giving the ability to shoot infected positioned outside of the safe room.

Safe rooms are extemporized from pre-Infection permanent structures (e.g. a hotel kitchen), from random opportunities (e.g. a railroad caboose) and by deliberate construction (e.g. the safe room at the end of the sky bridge at Metro International Airport).

All safe rooms are equipped with First-aid kits, ammunition and weapons. Weaponry is usually Tier 1, but Tier 2 weapons will be supplied in those safe rooms prefacing final or second to last chapters. Occasionally, a safe room inventory will also offer grenades or pills/adrenaline. Many (but not all) safe rooms will have secondary weapons available for survivors to use.

All safe room walls bear graffiti left by previous Survivors. Valve stated in Left 4 Dead's commentary that the concept of safe room graffiti was intended to fill in some of the plot and contextual backstory that Left 4 Dead would otherwise lack.

CEDA's Safe room checklist.

CEDA's Safe room checklist.

Evidently, CEDA encouraged the construction of safe rooms. Multiple posters throughout the Left 4 Dead games carry instructions showing how to build a safe room. CEDA's checklist included the following:

CEDA safe room checklist.

CEDA safe room checklist.

Another checklist involves:

Since these instructions are located in completed safe rooms, it is impossible to determine whether CEDA or uninfected local residents actually built specific safe rooms. Nevertheless, the standardized construction of safe room doors does suggest that CEDA had an inventory of these items on hand prior to the infection, which they distributed quite freely once it became clear that orthodox quarantine measures were failing.

Tactics

As a general rule, the safe room is the only part of a map where Survivors are completely safe from Infected attack. 

Door management is key factor in game play. If a door remains open, any Infected may enter the room until the door is finally closed. If an Infected horde is blocking the arc of a door's aperture, the door cannot be closed until this impediment is removed and the door's outline is picked out in white. Finally, if an Infected enters the safe room, it must be killed or pushed out of the room before the chapter will end and the next one can be loaded.

Common Infected who notice the Survivors inside will often try to reach into the safe room through the bars in the exit door. They usually pose no threat and can be disposed of very easily by gunfire or melee.

Safe Room Tactics

The Survivors

The Infected

Safe Room Locations

Left 4 Dead

No Mercy

Crash Course

Death Toll

Dead Air

Blood Harvest

The Sacrifice

Left 4 Dead 2

In Left 4 Dead 2, each level contains a safe room, with slight differences from the first game's safe rooms. Some safe rooms are larger than the first game's, such as an entire convenience store, as opposed to a single room.

Dead Center

The Passing

Dark Carnival

Swamp Fever

Hard Rain

The Parish

Cold Stream (Non-canon)

The Last Stand (Non-canon)

Achievements

Left 4 Dead

Survivors

L4d back 2 help
BACK 2 HELP (20G)
Leave a safe room to save an incapacitated teammate and bring them back safely.

Infected

L4d lamb 2 slaughter
LAMB 2 SLAUGHTER (20G)
As an Infected, incapacitate a Survivor who has entered and left a safe room.


Left 4 Dead 2

Heart warmer
HEARTWARMER (20G)
In a Versus round, leave the safe room to defibrillate a dead teammate.


Notes